Eyeshield 21 a weak child and firm named Sena Kobayakawa who enters the high school choice, Deimon Private Senior High School, where his childhood friend Mamori Anezaki school in the previous year. Remarkable ability just physically intense spurt of energy and agility, the result of school life were spent in accordance with the demands of bullies. It was revealed later that a friend, Riku, taught him how to run fast to help him against bullies. His ability to quickly catch the eye of a team of American high school foot ball captain Yoichi Hiruma, who forces Sena to join the Deimon Devil Bats to be running again.
To protect the identity of the other teams that want to recruit him, Sena is forced to publicly assume the role of team secretary, and enter the field wearing a helmet equipped with a green eye protection to hide her face under the pseudonym of "Eyeshield 21." Emergency crews initially took part in the football tournament spring ball hoping to win with through the strength of their new "secret weapon." However, a very weak team eliminated early on by the Ojo White Knights, a powerhouse football team that focuses on defense.
After Deimon's defeat, the Spring tournament is revealed as secondary in importance to the fall tournament, where the teams compete for the chance to play in the "Christmas Bowl" of high school football league championship. Hiruma, Kurita and Sena regroup and slowly build a real team from other misfits and students looking to define themselves, as TarÅ "Monta" Raimon, a baseball player who can only catch, and the Ha-Ha Brothers. Other characters slowly join the team, and the series follows the building and growth of the Deimon Devil Bats and its members as well as many of the opposing team as they all strive to achieve their goal of playing in the Christmas Bowl.
After the Christmas Bowl, Japan began to gather the best football players to form a team that will represent Japan at the American Football Youth World Championship, where an MVP will be rewarded NFL contract and $ 3 million. The Japanese team managed to make it to the final against Team America. The result is that last touchdown by Sena at the buzzer tying score, and both teams are declared winners, since no one expected anyone to win against America, but both teams are not satisfied with this and tear straight back onto the field for their own improvised "overtime , "causing chaos with officials. It is not clear which team won the unofficial extra period but Panther Team USA won the MVP trophy aloft, winning the pro contract with the San Antonio Armadillos.
This series concludes with Sena captained the Devil Bats when Hiruma and Kurita go off to college. In his final year in high school, Sena is invited to Notre Dame High School by Clifford, thus fulfilling Hiruma's proclamation at the beginning of the series: the famous Eyeshield 21 of Notre Dame High has been born. All the main characters are shown in the last chapter to be in college or playing amateur-league football while maintaining a job.
